Glycoinformatics: bridging isolated islands in the sea of data

K.S Egorova, Ph.V. Toukach

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

KEYWORDS: glycomics, glycoinformatics, carbohydrate, glycan, database, project integration

Angewandte Chemie International Edition, 2018, ePub ahead of print

DOI: 10.1002/anie.201803576, PMID: 29786940 (English), DOI: 10.1002/ange.201803576 (German)


Glycoinformatics is a young scientific branch, which assists the scientific community in carbohydrate research. In spite of fundamental roles of glycans in living organisms, the informatization of the field is significantly hindered by the lack of standards, data indices, protocols and tools widely recognized by researchers and publishers. The connection of the existing glycoinformatics projects with each other and with global life-science projects is far from complete. Moreover, in contrast to genes and proteins, there is no obligatory unique identifier for each natural carbohydrate structure. In the current essay, we assess the basic principles of successful informatization of glycoscience and discuss their implementation in the present glycoinformatics projects.

Situation in -omics
Informatization in glycomics vs. genomics and proteomics.
Situation in -omics
Overview of selected structure-centered glycoinformatics projects, their lifespan, coverage and peculiarities.
Situation in -omics
Ideal integration between glycoinformatics projects.

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