SYNTHESIS OF CHLORINľCARBOHYDRATE CONJUGATES BY 'CLICK CHEMISTRY'

M.A. Grina, I.S. Lonina, A.I. Makarova, F.V. Toukachb, V.V. Kachalab, A.V. Orlovab, A.F. Mironova

aM.V. Lomonosov Academy of Fine Chemical Technology, Moscow, Russia
bN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

Mendeleev Communications, 2008, v.18, p.1-3

DOI: 10.1016/j.mencom.2008.05.008


A synthesis of a conjugate of chlorin e6 with b-D-lactose has been carried by 1,3-dipolar cycloaddition between a propargyl derivative of chlorin e6 and a sugar azide has been performed. The structure and conformation of the product have been studied by 1D and 2D NMR spectroscopy.


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